NURS215 Week 1 Discussion Thread: Neoplasia
Based on course readings, write a synopsis of 1 of the following topics: invasion and metastasis, heredity in cancer, oncogenic viruses, tumor markers.
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Solution: NURS215 Wek 1 Discussion Thread: Neoplasia
Synopsis of Oncogenic Viruses
Oncogenic viruses are a diverse group of pathogens linked to approximately 12-16% of human cancers worldwide, with significant impact in low-income regions (Santos Apolonio et al., 2021). Seven established oncogenic viruses are recognized for their role in malignancies: Epstein-Barr virus (EBV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), human papillomavirus (HPV), human T-cell lymphotropic virus type 1 (HTLV-1), Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8), and Merkel cell polyomavirus (MCV) (Santos Apolonio et al., 2021).
Mechanisms of Oncogenesis
Oncogenic viruses contribute to cancer development through persistent infection, immune evasion, and alteration of cellular pathways. DNA viruses like HPV, EBV, and HBV integrate their genomes into host cells, disrupting normal cell cycle regulation via oncoproteins such as HPV’s E6 and E7, which inactivate tumor suppressors p53 and Rb (Isaguliants et al., 2021). RNA viruses, such as HCV and HTLV-1, promote cancer indirectly through chronic inflammation and direct interference with cellular oncogenes (Isaguliants et al., 2021).
These viruses are adept at evading the host’s immune defenses. For example……Click the paypal icon to purchase full solution for $5
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